九乡新闻网重生之我是坏媳妇:有关人类精液中肥胖抑制素的研究
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研究者对激素肥胖抑制素和胃促生长素的产生，以及在男性生殖中可能的作用进行了研究。
Copyright (c)2005-2011 by Excerpta Medica BV. http://www.excerptamedica.com All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means,electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the copyright owner. No responsibility is assumed by the Publisher for any injury and/or damage to persons or property as a matter of products liability, through negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Because of rapid advances in the medical sciences, the Publisher recommends that independent verification of diagnoses and drug dosages should be made. Opinions expressed in this publication are those of the original authors and do not necessarily reflect those of the Publisher, the sponsor, or the editors. Excerpta Medica BV assumes no liability for any material published herein. Just Published has been made possible by univadis®, a service offered by MSD.
背景
胃促生长素和肥胖抑制素均为一种名为促生长激素释放多肽原的激素原所产生的激素。在男性生殖系统中，已发布证据显示胃促生长素参与了睾丸功能以及精子形成调节，但是对肥胖抑制素作用的了解甚少。
- 最新公布的研究的目标是调查胃促生长素和肥胖抑制素在人精液中的产生，和两者相互之间以及与影响精液质量的因素之间的关系。
- 研究人群为在生育中心就诊的连续 112 名男性（平均年龄 33 岁）。 所有患者提供精液和血清样本，并进行全身体格检查。
- 研究者在所有参与研究的患者的精液中发现了肥胖抑制素和胃促生长素的存在。 两种多肽在精液中的浓度都显著高于在相同患者的血清样本中的浓度。
- 在血清样本中，胃促生长素水平高于肥胖抑制素的水平，并且在两种多肽的浓度之间统计学上存在显著的线性相关关系。 相反的，在精液样品中，肥胖抑制素水平高于胃促生长素水平；在两种多肽之间统计学上存在显著的线性相关趋势，而此趋势在高胃促生长素水平时变为指数关系。
- 研究者也观察到在血清胃促生长素和年龄之间存在显著的负相关关系。 肥胖抑制素的精液和血清水平与精子活力呈显著正相关。 精液肥胖抑制素水平与精子浓度也显著相关。
- 吸烟者以及白细胞精子症患者精液中肥胖抑制素水平较低。
结论
研究者称他们最重要的发现是在肥胖抑制素水平和精子浓度以及活力之间存在正相关关系：这提示“肥胖抑制素可能在细胞内而非精子内，在控制细胞增殖以及存活方面起作用”。Moretti E, Collodel G, Iacoponi F, et al. Detection of obestatin in seminal plasma and its relationship with ghrelin and semen parameters. Fertil Steril. 2011;95:2303-9.
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Copyright (c)2005-2011 by Excerpta Medica BV. http://www.excerptamedica.com All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means,electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the copyright owner. No responsibility is assumed by the Publisher for any injury and/or damage to persons or property as a matter of products liability, through negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Because of rapid advances in the medical sciences, the Publisher recommends that independent verification of diagnoses and drug dosages should be made. Opinions expressed in this publication are those of the original authors and do not necessarily reflect those of the Publisher, the sponsor, or the editors. Excerpta Medica BV assumes no liability for any material published herein. Just Published has been made possible by univadis®, a service offered by MSD.
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